Anti-aging gene therapy developed at the University of Hawaii

Anti-aging gene therapy developed at the University of Hawaii


>>Narrator: Astaxanthin, a naturally occurring
chemical, shows promise for anti-aging based on a study by researchers at the University
of Hawai‘i at Manoa’s John A. Burns School of Medicine in partnership with the life sciences
company Cardax, Inc. The Astaxanthin supplement developed by Cardax
shows the ability to significantly increase the expression of the FOX03 gene, which plays
a proven role in longevity.>>Bradley Willcox, JABSOM: What we have now
I think is a potential what you might call an anti-aging or healthy aging compound, Astaxanthin,
that could potentially improve human lifespan and human healthspan.>>David Watumull, Cardax Inc.: The University
of Hawai‘i and the great science that’s going on there combined with our local companies,
we now have I think some very intriguing evidence on the role of the FOX03 gene in aging, and
Astaxanthin’s impact and ability to activate that gene. That’s never been done before, it’s never
been shown before.>>Narrator: The research showed that mice
that were fed a higher amount of an Astaxanthin compound experienced a significant boost in
the activation of the FOX03 gene in their heart tissue.>>Richard Allsopp, JABSOM: This project is
really important to the John A. Burns School of Medicine here at the University of Hawai‘i
because it can lead to our further understanding of how we can increase not only potentially
the lifespan of people but also the number of healthy years of living that we can go
through.>>Narrator: Some of the possible next steps
include a longer-term study of the compound’s effects on the longevity of mice and likely
human studies using Cardax’s already approved and marketed dietary supplement called “ZanthoSyn,”
a highly absorbent form of Astaxanthin.>>Willcox: I think in Hawai‘i with the University
of Hawai‘i we can really put it all together and do some of the best aging research in
the world.

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