Introduction to Organs-on-Chips

Introduction to Organs-on-Chips


[music] [piano] [Don Ingber] This is the idea
of replacing animal studies for drug testing,
for example, with little
micro-engineered devices that are lined
by human cells and reconstitute
organ-level functions. [Geraldine Hamilton] One of the things
that pharmaceutical industry is finding is that they’re having
very high failure rates, and often it’s because the animal models
being used to develop these drugs are not predictive
of the human situation. [Don Huh] It’s very expensive
to perform animal studies, and also time-consuming. [Geraldine Hamilton]
Whereas here we have models that can potentially better predict
the human situation. [Don Huh] Uh, it’s called
a human breathing lung on a chip, uh, and this device mimics
the breathing human lung. [Don Ingber]
There’s human airway cells from the air sac
on a membrane that’s porous. On the other side of the membrane
are human capillary blood vessel cells. There’s air on one side, there’s flowing medium
with human blood cells in it, like blood on the other si-
on the capillary side. And then the whole thing
stretches and relaxes just like our lung does
when we breathe. [Don Huh]
And we mimic, you know, various types
of physiological responses to drugs, toxins
or various types of materials that we encounter
on a daily basis. [Geraldine Hamilton]
So these would be very useful because it’s human relevant,
because we will be using human cells. [Don Huh] And I think
the beauty of this technology is it’s so easy
and straightforward that a lot of people can use it
without getting trained, especially biologists, clinicians,
you know, chemists, you know, who don’t have any
engineering background. This technology
is accessible to them. [Geraldine Hamilton]
Much cheaper than using animal models. You see the size?
You need very little compound. So this would
not only be more predictive but have higher
turn-around times. You can screen using much smaller
amounts of the drugs too. So, more predictive
and more practical. [Don Ingber]
But, we also have kidney on a chip, bone marrow on a chip,
peristalsis in gut on a chip, and we’re just going on organ-to-organ
and hopefully integrating them. In a little microsystem we link the heart that beats
to the lung that breathes. We’re getting great interest
from pharmaceutical industry and hope to announce
our first alliance to use those to see if we can, indeed,
replace some animal studies to accelerate
the drug development process, and decrease costs. [Don Huh] This institute is by far
the greatest and, you know, best working environment
for bioengineering research, and we can predict
the behavioral response of these cells, or the body, to, for example,
the drugs more precisely. I think that’s where the,
the promise is. captioned by
includeme.com

28 thoughts on “Introduction to Organs-on-Chips”

  1. I would like the company to mention that their invention is also ethical! (along with being cheaper and convenient etc) Great idea! Hope for the end of animal testing…

  2. I never give donations for research because I don't agree with experimenting on animals. If the researchers used used Organs on a chip I'd support them whole heartedly

  3. Ahhh… I love you guys….you are the perfect combination of intellect, practicality and heart. Thank you. Thank you. Thank you.

  4. Fantastic! we already have such a great solution. Now im sure we could do alot of good research without animal testing and its only a question of time before animal testing get banished.

    However I would NEVER support these cruel animal experiments anyway, even if there wasn't a solution like this. Cause research is important, but never important enough to torture any living beings (nothing are) and it's not the slightest better when done to animals than humans or opposite for that sake.

  5. The Animal Model should be dropped now, if something does not work than it should be abandoned now. Here is hoping the UK will catch up soon on the vision of medical research in par with other countries.

  6. Hi, I am part of an animal rights group called No Mas Viviseccion, from the sensibilization department. NMV focuses mainly in abolishing animal testing in Chile and have currently a bill project to forbid animal testing for cosmetics.
    I have found your video really interesting and would like to ask permission to download it and add Spanish subtitles in order to share your video at our Facebook fanpage. It is important to help people know aboutt the advances possible in science wihout using animals.
    I'll be waiting for your reply.
    Kind Regards,

  7. I think this is great. I fully support non-animal model research studies. I hope more companies work toward these types of solutions that are feasible and humane. We know animals are intelligent, especially primates. We know they feel pain, we know they feel fear, and we know they suffer. There is no excuse to carry on animal testing when alternatives are available. And every effort should be made to continue to discover new non-animal models of testing. Animal testing is antiquated and barbaric. I hope we can evolve enough as a society to look at what we are doing to other living beings and choose to change that wholly and permanently.

  8. It's a great idea. let's see if they can commercialize it by the end of this decade at a reasonable price.

  9. 2011. If it was really so good and so much cheaper, why didn't this become the new standard? Why did this fade into obscurity?

  10. All these people in the comment section are about animal rights!!! The big picture is faster cheaper drug toxicity test….not animals

  11. I strongly agree that this technology can replace animal testing, for lipstick and shampoo isn't worth it for a animal's life.

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