The Guthrie Test – Christmas Lectures with Walter Bodmer

The Guthrie Test – Christmas Lectures with Walter Bodmer


All newborns have this so called Guthrie test. Now I’ve got an example to show you here. Which we’re grateful for the Great Ormond
Street people for giving us. You see, you take just a heel prick, a little blood from the newborn baby. And you put it on a bit of blotting paper
like this. And you can have the patient’s name and all
the information there. And when the blotting paper is dry, it can
just be sent through the post. Because what you’re testing for in this blood, is the level of that aminoacid that can’t
be metabolised. And that survives the post perfectly well. So what you do is, when it goes to the testing
laboratory, you punch out a little bit of that paper that
has the blood sample in it. And then what you do, is you put that bit
of paper onto bacteria on a plate. And I’ve got a sample plate here. And the bacteria are treated in such a way that they’ll only grow if they’re given phenylalanine. So they’ll only grow around the bit of paper that has phenylalanine in it. Now these are test spots here. And you can see that halo of growth of the
bacteria there. Those are the test ones. And can you see one positive result on that
plate? You see that one? That one there? See it there? That’s a positive result. The amino acid from that little bit of filter
paper has spread around and allowed the bacteria
to grow. It’s a very simple straightforward test that’s
done on everybody now. It’s been done since the 1960s. So all newborns can be screened to see whether they’ve got that disease.

21 thoughts on “The Guthrie Test – Christmas Lectures with Walter Bodmer”

  1. This is a very confusing way to explain this, this is a horrible lecture. First line is "All newborns have this so called Guthrie test." What is a guthrie test and how do newborns have it? The description gives more information than the 2 minute long video, and does so without contradicting itself.

  2. Phenylketonuria, my ex has this and it was the first time I've ever heard about it. in short the body is unable to metabolize and regulate a specific protein. beside missing the proteins that phenylalanine gets transformed to, a high concentration is neurotoxic. phenylalanine is in everything that contains protein.
    for people with PKU that means they have a personal daily tolerance of protein in total that they can and must take in. the rest is substituted with special protein-shakes (I just remembered the smell, yuk!). everything they eat has to be weighed to add up the phe. there are low-protein noodles, flour, bread etc and they only cost triple of the normal stuff.
    if they have too much phe they get agitated, distracted, sleepy and a hangover (afaik but the nausea. ever ended a beer night with a joint only to find out the night only has 5 hours? yeah like that).

  3. Don't let the audience shape your channel with "I like these two minutes videos that makes me feel smart" encouragements!!!

    YOU, "The Royal Institution" channel, are the ones that are supposed to shape the audience, not the other way around! That is your mission! That is why people are flocking to this channel.

    Many excerpts doesn't make much sense when put out of a full talk context, even thought the excerpts are correct in every aspect.

    The Royal Institution channel is not about instant gratification. Totally understandable you want to keep the channel alive, but maybe it will do more good if, instead of only two 2 minutes of nonsense excerpts, you will rather upload two 30 minutes parts of a full lecture. I bet everybody will love that.

    Don't fell victim to the populist decay of a Google algorithm based on likes and user interaction chasing. The algorithms are to be changed to adapt to you, not you to change to adapt whatever today algorithm.

  4. Usually I love all languages and dialects.

    And if I don't, I don't mind them.

    But for some rreason, his Rs irrritate me a grreat deal.

  5. Very sub-par upload. If you continue to post these out of context, mangled "snippets". you will lose mine and many other subscriptions.

  6. I now know LESS than when I started watching this. What disease? What is he on about? This is NOT the way to edit a video into 2 minutes. Seriously, who passed this?

  7. It's important to mention that the disease has devastating consequences, which can be prevented if a child is known to have the disease!

  8. For those of you asking what diseases are being referred to, it's in the video description. Though I do agree that it would have been better to have a video edit that contained the information.

  9. maybe he could just sit and talk 2 hours about exams in India and who got and didnt get a scholarship where and how prestigious it was or wasnt, like the Indian in the amazing earth shattering mesmerizing fascinating video about the ribisome.

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